Browsing by Author Matthias Rottmann

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Showing results 1 to 7 of 7
Issue DateTitleAuthor(s)
22-Jun-2017Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal StructuresGeoffrey Schwertz; Matthias C. Witschel; Matthias Rottmann; Roger Bonnert; Ubolsree Leartsakulpanich; Penchit Chitnumsub; Aritsara Jaruwat; Wanwipa Ittarat; Anja Schäfer; Raphael A. Aponte; Susan A. Charman; Karen L. White; Abhijit Kundu; Surajit Sadhukhan; Mel Lloyd; Gail M. Freiberg; Myron Srikumaran; Marc Siggel; Adrian Zwyssig; Pimchai Chaiyen; François Diederich; ETH Zurich; BASF SE; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; Medicines for Malaria Venture; Thailand National Center for Genetic Engineering and Biotechnology; Monash University; TCG Lifesciences Ltd.; Covance Inc.; AbbVie; Mahidol University
12-Oct-2017Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone MotifsGeoffrey Schwertz; Michelle S. Frei; Matthias C. Witschel; Matthias Rottmann; Ubolsree Leartsakulpanich; Penchit Chitnumsub; Aritsara Jaruwat; Wanwipa Ittarat; Anja Schäfer; Raphael A. Aponte; Nils Trapp; Kerstin Mark; Pimchai Chaiyen; François Diederich; ETH Zurich; BASF SE; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; Thailand National Center for Genetic Engineering and Biotechnology; Mahidol University; Vidyasirimedhi Institute of Science and Technology
9-Apr-2015Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): Cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activitiesMatthias C. Witschel; Matthias Rottmann; Anatol Schwab; Ubolsree Leartsakulpanich; Penchit Chitnumsub; Michael Seet; Sandro Tonazzi; Geoffrey Schwertz; Frank Stelzer; Thomas Mietzner; Case McNamara; Frank Thater; Céline Freymond; Aritsara Jaruwat; Chatchadaporn Pinthong; Pinpunya Riangrungroj; Mouhssin Oufir; Matthias Hamburger; Pascal Mäser; Laura M. Sanz-Alonso; Susan Charman; Sergio Wittlin; Yongyuth Yuthavong; Pimchai Chaiyen; François Diederich; BASF SE; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; ETH Zurich; Thailand National Center for Genetic Engineering and Biotechnology; California Institute for Biomedical Research; Mahidol University; GlaxoSmithKline plc, Spain; Monash Institute of Pharmaceutical Sciences
1-Jan-2014KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmissionKelli L. Kuhen; Arnab K. Chatterjee; Matthias Rottmann; Kerstin Gagaring; Rachel Borboa; Jennifer Buenviaje; Zhong Chen; Carolyn Francek; Tao Wu; Advait Nagle; S. Whitney Barnes; David Plouffe; Marcus C.S. Lee; David A. Fidock; Wouter Graumans; Marga Van De Vegte-Bolmer; Geert J. Van Gemert; Grennady Wirjanata; Boni Sebayang; Jutta Marfurt; Bruce Russell; Rossarin Suwanarusk; Ric N. Price; Francois Nosten; Anchalee Tungtaeng; Montip Gettayacamin; Jetsumon Sattabongkot; Jennifer Taylor; John R. Walker; David Tully; Kailash P. Patra; Erika L. Flannery; Joseph M. Vinetz; Laurent Renia; Robert W. Sauerwein; Elizabeth A. Winzeler; Richard J. Glynne; Thierry T. Diagana; The Genomics Institute of the Novartis Research Foundation; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; Columbia University, College of Physicians and Surgeons; Radboud University Nijmegen Medical Centre; Menzies School of Health Research; Eijkman Institute for Molecular Biology; Agency for Science, Technology and Research, Singapore; Shoklo Malaria Research Unit; Mahidol University; Nuffield Department of Clinical Medicine; Armed Forces Research Institute of Medical Sciences, Thailand; University of California, San Diego; University of California, San Diego, School of Medicine; Novartis Institute for Tropical Diseases Pte. Ltd.; California Institute for Biomedical Research
8-May-2018Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic ScaffoldGeoffrey Schwertz; Matthias C. Witschel; Matthias Rottmann; Ubolsree Leartsakulpanich; Penchit Chitnumsub; Aritsara Jaruwat; Watcharee Amornwatcharapong; Wanwipa Ittarat; Anja Schäfer; Raphael A. Aponte; Nils Trapp; Pimchai Chaiyen; François Diederich; Vidyasirimedhi Institute of Science and Technology; ETH Zürich; Universitat Basel; Swiss Tropical and Public Health Institute (Swiss TPH); Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology; BASF SE
3-Sep-2010Spiroindolones, a potent compound class for the treatment of malariaMatthias Rottmann; Case McNamara; Bryan K.S. Yeung; Marcus C.S. Lee; Bin Zou; Bruce Russell; Patrick Seitz; David M. Plouffe; Neekesh V. Dharia; Jocelyn Tan; Steven B. Cohen; Kathryn R. Spencer; Gonzalo E. González-Páez; Suresh B. Lakshminarayana; Anne Goh; Rossarin Suwanarusk; Timothy Jegla; Esther K. Schmitt; Hans Peter Beck; Reto Brun; Francois Nosten; Laurent Renia; Veronique Dartois; Thomas H. Keller; David A. Fidock; Elizabeth A. Winzeler; Thierry T. Diagana; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; The Genomics Institute of the Novartis Research Foundation; Novartis Institute for Tropical Diseases Pte. Ltd.; Columbia University Medical Center; Agency for Science, Technology and Research, Singapore; National University of Singapore; Scripps Research Institute; Pennsylvania State University; Novartis International AG; Shoklo Malaria Research Unit; Mahidol University; Nuffield Department of Clinical Medicine
29-Nov-2013Targeting Plasmodium PI(4)K to eliminate malariaCase W. McNamara; Marcus C.S. Lee; Chek Shik Lim; Siau Hoi Lim; Jason Roland; Advait Nagle; Oliver Simon; Bryan K.S. Yeung; Arnab K. Chatterjee; Susan L. McCormack; Micah J. Manary; Anne Marie Zeeman; Koen J. Dechering; T. R.Santha Kumar; Philipp P. Henrich; Kerstin Gagaring; Maureen Ibanez; Nobutaka Kato; Kelli L. Kuhen; Christoph Fischli; Matthias Rottmann; David M. Plouffe; Badry Bursulaya; Stephan Meister; Lucia Rameh; Joerg Trappe; Dorothea Haasen; Martijn Timmerman; Robert W. Sauerwein; Rossarin Suwanarusk; Bruce Russell; Laurent Renia; Francois Nosten; David C. Tully; Clemens H.M. Kocken; Richard J. Glynne; Christophe Bodenreider; David A. Fidock; Thierry T. Diagana; Elizabeth A. Winzeler; The Genomics Institute of the Novartis Research Foundation; Columbia University Medical Center; Novartis Institutes for Tropical Disease; University of California, San Diego; Biomedical Primate Research Centre - Rijswijk; TropIQ Health Sciences; Swiss Tropical and Public Health Institute (Swiss TPH); Universitat Basel; Boston University School of Medicine; Novartis International AG; Radboud University Nijmegen Medical Centre; Agency for Science, Technology and Research, Singapore; Yong Loo Lin School of Medicine; Nuffield Department of Clinical Medicine; Mahidol University