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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/10006
Title: The cytogenetic effects of aflatoxin and gamma-rays on human leukocytes in vitro
Authors: C. Promchainant
V. Baimai
A. Nondasuta
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Environmental Science
Issue Date: 1-Jan-1972
Citation: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Vol.16, No.4 (1972), 373-380
Abstract: Chromosomes from human leukocyte cultures in vitro were treated with γ-rays (200 R), aflatoxin (50 μg/ml, dissolved in dimethyl sulfoxide (DMSO)) and with a combination of both. At the time of treatment (48 h) cells were in all stages of interphase but G 1 cells were evidently predominant. All types of chromosome aberration were observed. Frequencies of chromosome-type aberrations were much higher than those of chromatid type after γ-ray treatment, but these types of chromosome aberration did not differ greatly when the cultures were treated with aflatoxin. Apparently the cytogenetic effect of aflatoxin was delayed longer than was that of irradiation. The present data also suggest the additive effect of γ-rays and aflatoxin in the combined treatment. © 1972.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0015445145&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/10006
ISSN: 00275107
Appears in Collections:Scopus 1969-1990

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