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Title: Chronic kidney disease impairs bone defect healing in rats.
Authors: Dutmanee Seriwatanachai
ดุษมณี เสรีวัฒนาชัย
Liu, Weiqing
Kang, Ning
Dong, Yuliang
Zhou, Liyan
Lin, Yunfeng
Ye, Ling
Liang, Xing
Yuan, Quan
Mahidol University. Faculty of Dentistry. Department of Oral Biology
Keywords: Bone;Chronic kidney disease;Experimental models of disease;Open Access article
Issue Date: 9-Mar-2016
Citation: Liu W, Kang N, Seriwatanachai D, Dong Y, Zhou L, Lin Y, et al. Chronic kidney disease impairs bone defect healing in rats. Scientific Reports. 2016 Mar 9;6:23041.
Abstract: Chronic kidney disease (CKD) has been regarded as a risk for bone health. The aim of this study was to evaluate the effect of CKD on bone defect repair in rats. Uremia was induced by subtotal renal ablation, and serum levels of BUN and PTH were significantly elevated four weeks after the second renal surgery. Calvarial defects of 5-mm diameter were created and implanted with or without deproteinized bovine bone mineral (DBBM). Micro-CT and histological analyses consistently revealed a decreased newly regenerated bone volume for CKD rats after 4 and 8 weeks. In addition, 1.4-mm-diameter cortical bone defects were established in the distal end of femora and filled with gelatin sponge. CKD rats exhibited significantly lower values of regenerated bone and bone mineral density (BMD) within the cortical gap after 2 and 4 weeks. Moreover, histomorphometric analysis showed an increase in both osteoblast number (N.Ob/B.Pm) and osteoclast number (N.Oc/B.Pm) in CKD groups due to hyperparathyroidism. Notably, collagen maturation was delayed in CKD rats as verified by Masson’s Trichrome staining. These data indicate that declined renal function negatively affects bone regeneration in both calvarial and femoral defects.
ISSN: 2045-2322 (electronic)
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