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Title: Antibody cross linking as a factor in immunity to cholera in infant mice
Authors: J. E.C. Bellamy
J. Knop
E. J. Steele
W. Chaicumpa
D. Rowley
University of Adelaide
University of Saskatchewan
Max Planck Institute of Immunobiology and Epigenetics
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1975
Citation: Journal of Infectious Diseases. Vol.132, No.2 (1975), 181-188
Abstract: Several antibody preparations were tested for their ability to reduce adsorption of Vibrio cholerae to isolated intestinal epithelial cells, and this ability was related to agglutination and protective activity in infant mice. The results demonstrate that (1) the reduction in adsorption of V. cholerae to epithelial cells correlates with the degree of agglutination for a given antibody preparation; (2) intact antibodies protect infant mice from cholera only at concentrations that agglutinate the bacteria; and (3) purified antibodies to flagellar antigens protect infant mice from cholera. These results indicate that cross linking of bacteria by antibody causes a reduction in the number of organisms adsorbed to the intestinal wall. Thus antibody cross linking plays an important role in immunity to cholera in infant mice.
ISSN: 00221899
Appears in Collections:Scopus 1969-1990

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