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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/10827
Title: Drug—biomolecule interactions: Drug toxicity and vitamin coenzyme depletion
Authors: John P. Bederka
Danis Davitiyananda
Mikel L. Moses
Nasim Ahmad
University of Illinois Medical Center
Mahidol University
The University of Georgia
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1975
Citation: Journal of Pharmaceutical Sciences. Vol.64, No.3 (1975), 528-534
Abstract: Thirteen pyridine compounds, phenylbutazone, and three salicylates were studied for their effects upon the turnover of 7‐ 14 C‐nicotinamide dinucleotides in the mouse. The compounds were administered at equitoxic doses (LD 25 ) to 7‐ 14 C‐nicotinic acid‐ (niacin) pretreated mice, and the induced excretion of urinary‐ 14 C was analyzed in terms of total 14 C and percentage of total 14 C as known metabolites of nicotinic acid. Of the 17 compounds, 12 afforded significant alterations in the total 14 C excreted and five of these caused alterations in the disposition of the 7‐ 14 C‐nicotinamide endogenously liberated from the 7‐ 14 C‐nicotinamide adenine dinucleotide pool. Comparative depletions of 14 C from brain, lungs, liver, and kidneys were studied with 10 of the pyridine compounds. Several tissues were found to be the sources of the urinary‐ 14 C, with the lungs being the most accessible source. Some compounds had effects at doses less than the LD 25 's, as shown by increased hexobarbital sleeping time in acute experiments with rats. These pyridine compounds were initially considered to act at the level of the nicotinamide dinucleotide s in the normal biosynthetic pathway (nicotinic acid site) and/or at the level of glycohydrolase (nicotinamide site). In view of the inclusion of nicotinic acid, nicotinamide, salicylic acid, and phenylbutazone in this correlation between toxicity and 7‐ 14 C‐nicotinamide mobilization, it is not necessary that the formation of compounds analogous to the nicotinamide dinucleotides plays a significant role in the toxic manifestations of the nicotinamide analogs. The displacement of 7‐ 14 C‐nicotinamide dinucleotides from their corresponding apoenzymes with subsequent metabolism of the dinucleotides could explain the noted increased 7‐ 14 C‐nicotinamide dinucleotide turnover and depletion which led to the toxic effects. Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0016663486&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/10827
ISSN: 15206017
00223549
Appears in Collections:Scopus 1969-1990

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