Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/10834
Title: Hemoglobin vancouver [α<inf>2</inf>β<inf>2</inf> 73(E17) Asp→ Tyr]: Its structure and function
Authors: R. T. Jones
B. Brimhall
S. Pootrakul
G. Gray
OHSU School of Medicine
Mahidol University
Vancouver General Hospital
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-1976
Citation: Journal of Molecular Evolution. Vol.9, No.1 (1976), 37-44
Abstract: Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution of the normal aspartyl residue 73 of the β chain by a tyrosyl residue. It was discovered in a man of Chinese descent in association with β thalassemia. It was subsequently detected in a sister in association with normal Hb A. The oxygen affinity of the abnormal hemoglobin is decreased but its subunit interaction is normal. The Bohr effect may be slightly increased. This is the fourth abnormal hemoglobin to be found with a substitution at β73. The others are Hb C-Harlem (α < inf > 2 < /inf > β < inf > 2 < /inf > 6Glu→Val and 73 Asp→Asn), Hb Korle-Bu (α < inf > 2 < /inf > β < inf > 2 < /inf > 73 Asp→Asn), and Hb Mobile (α < inf > 2 < /inf > β < inf > 2 < /inf > 73 Asp→Val). Although Hb Mobile was found in the present studies to have a decreased affinity for oxygen, Hbs C-Harlem and Korle-Bu have been reported to be normal. These observations of functional differences for variants of β73 added to earlier observations of the role of the normal β73 residue to the aggregation of sickle deoxyhemoglobin indicate that this position of the molecule may be important in intra as well as intermolecular interactions. © 1976 Springer-Verlag.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017360611&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/10834
ISSN: 14321432
00222844
Appears in Collections:Scopus 1969-1990

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.