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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/10850
Title: Primary hepatic carcinoma in Thailand
Authors: T. Stitnimankarn
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-1976
Citation: Gann Monographs on Cancer Research. Vol.Vol.18, (1976), 123-127
Abstract: Primary hepatic carcinoma is a common disease in Thailand. A survey of 12,265 autopsies revealed 297 cases of primary hepatic carcinoma, an incidence of 2.42%. Of these, 124 cases (41.8%) were associated with hepatic cirrhosis and 56 cases (18.9%) were found arising in conjunction with liver fluke (Opisthorchis viverrini) infestation of the liver. Two hundred and seventy two new patients with liver cancer were seen at the Siriraj Hospital in 1971 and 1972. The patients had a mean age of less than 50 yr. The tumors were found more frequently among men than among women. 75% of the patients produced an α fetoglobulin detectable in the blood. An enzyme histochemical study was made on 44 surgical biopsy and autopsy specimens. Alkaline phosphatase was found to be absent in tumor tissue in all cases. Enzyme reactions appeared to be greater in the tumor nodules than in the liver tissue in a majority of cases for lactate and isocitric dehydrogenases and DPNH diaphorase, whereas glucose 6 phosphate, glutamate, β hydroxybutyric, and 6 phosphogluconate dehydrogenases showed greater intensities of reaction in the liver tissue. An electron microscopical study was made on 25 liver biopsy specimens of hepatocellular carcinoma and 2 cholangiocarcinomas.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0017083762&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/10850
ISSN: 00720151
Appears in Collections:Scopus 1969-1990

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