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Title: Jaw bone regeneration in relation to position of dental implant.
Authors: Nawakamon Suriyan
นวกมล สุริยันต์
Sirichai Kiattavorncharoen
ศิริชัย เกียรติถาวรเจริญ
Kiatanant Boonsiriseth
เกียรติอนันต์ บุญศิริเศรษฐ
Dutmanee Seriwatanachai
ดุษมณี เสรีวัฒนาชัย
Koravit Somkid
กรวิชย์ สมคิด
Raweewan Arayasantiparb
ระวีวรรณ อารยะสันติภาพ
Lertrit Sirinnaphakorn
เลิศฤทธิ์ ศรินนภากร
Dusit Sujirarat
ดุสิต สุจิรารัตน์
Natthamet Wongsirichat
ณัฐเมศร์ วงศ์สิริฉัตร
Mahidol University. Faculty of Dentistry. Department of Oral & Maxillofacial Surgery
Natthamet Wongsirichat
ณัฐเมศร์ วงศ์สิริฉัตร
Keywords: Osteointegration;Bone quality;Bone quantity;Bone density;Gene expression;Dental implant;Open Access article;วิทยาสารทันตแพทยศาสตร์มหิดล;Mahidol Dental Journal
Issue Date: Jan-2015
Citation: Suriyan N, Kiattavorncharoen S, Boonsiriseth K, Seriwatanachai D, Somkid K, Arayasantiparb R, et al. Jaw bone regeneration in relation to position of dental implant. M Dent J. 2015; 35(1): 69-77.
Abstract: Objective: To evaluate the correlation of molecular parameters of bone cells such as BMP2, FGF23, RUNX2 from osteotomies sites and bone type according to Cone Beam Computer Tomography (CBCT), surgeon tactile sensation. Materials and methods: Study designs: Experimental cross sectional study. The bone specimens were collected during operation. The specimens were placed in refrigerator at -80°C and then extracted for RNA. The cDNA product was used for TaqMan RT-PCR reaction analysis. Results: Among total 34 implant sites, 21 (62%) were from male with mean age 51 years old. The majority of bone type was type 3+4 with 28 (82.4%) from CBCT and 22 (64.7%) from surgeon tactile, respectively. Gene expression profi le demonstrated that BMP2, FGF23, and RUNX2 were expressed; 52.9%, 23.5% and 41.2%.The gingival thickness and smoking was found signifi cantly difference with wound healing but not signifi cant difference with BMP2, FGF23 and RUNX2 gene expression (p <0.05). Conclusion: Molecular parameters such as BMP2 and FGF23 gene expression were correlated with bone quantity and quality evaluation in term of wound healing including the thickness of soft tissue and amount of hard tissue. This study suggested the possibility of osteogenic gene profi le matching the human jawbone.
ISSN: 0125-5614 (printed)
Appears in Collections:DT-Article

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