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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/11186
Title: Inhibition of intestinal glucose absorption in several animal species by cytochalasins
Authors: C. Toskulkao
T. Glinsukon
B. Kongsuktrakoon
S. Sophasan
W. Thamavit
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-1980
Citation: Research Communications in Chemical Pathology and Pharmacology. Vol.30, No.3 (1980), 521-534
Abstract: The effect of various cytochalasins on intestinal glucose absorption in several animal species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 μg/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 μg/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0019179003&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/11186
ISSN: 00345164
Appears in Collections:Scopus 1969-1990

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