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Title: Bioactive 4-hydroxycinnamide and bioactivities of polyalthia cerasoides
Authors: Lertyot Treeratanapiboon
Apilak Worachartcheewan
Thummaruk Suksrichavalit
Rachada Kiatfuengfoo
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
Mahidol University
Srinakharinwirot University
Chulabhorn Research Institute
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 22-Aug-2011
Citation: EXCLI Journal. Vol.10, (2011), 16-22
Abstract: Constituents from Polyalthia cerasoides, stem bark methanol extract, were previously documented. This study reports the first isolation of bioactive N-(4-hydroxy-β-phenethyl)-4- hydroxycinnamide (1) from ethyl acetate extract of the plant species including stigmasterol and a mixture of triterpenes from hexane and dichloromethane extracts. Trace essential elements were found in the hexane extract in ppm level. The plant extracts were evaluated for their antimicrobial and antioxidative activities. The dichloromethane extract displayed the highest activity against Corynebacterium diphtheriae NCTC 10356 with MIC of 32 μg/mL, as well as, the highest SOD activity with an IC 50 of 4.51 μg/mL.
ISSN: 16112156
Appears in Collections:Scopus 2011-2015

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