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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/11292
Title: Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates
Authors: James V. Conlan
Richard G. Jarman
Khamphouth Vongxay
Piyawan Chinnawirotpisan
Melanie C. Melendrez
Stanley Fenwick
R. C.Andrew Thompson
Stuart D. Blacksell
Murdoch University
Armed Forces Research Institute of Medical Sciences, Thailand
Ministry of Agriculture and Forestry
Mahidol University
Nuffield Department of Clinical Medicine
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2011
Citation: Infection, Genetics and Evolution. Vol.11, No.6 (2011), 1306-1311
Abstract: The objective of this study was to determine the prevalence and genotypic range of Hepatitis E virus (HEV) in the pig population of northern Lao People's Democratic Republic (PDR). We collected 181 faecal samples from indigenous-breed pigs ≤6 months of age and the faeces was stored in RNA stabilisation buffer due to cold-chain and transport limitations. Twenty-one (11.6%) pigs had detectable HEV RNA and 43.5% of village pig herds were infected. Based on a 240 base pair-nucleotide sequence flanking the junction of open reading frames 1, 2 and 3 (ORF1, ORF2 and ORF3) the isolates were phylogenetically classified within genotype 4. Phylogenetic analyses revealed distinct genetic groupings of the Lao HEV isolates and two groups clustered with human and pig HEV isolates from China. This was the first study to demonstrate genotype 4 HEV in Lao PDR and indicates pigs are a potential reservoir for human HEV infection. © 2011 Elsevier B.V.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960404031&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/11292
ISSN: 15677257
15671348
Appears in Collections:Scopus 2011-2015

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