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Title: Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana
Authors: Panomwan Panseeta
Kanlaya Lomchoey
Samran Prabpai
Palangpon Kongsaeree
Apichart Suksamrarn
Somsak Ruchirawat
Sunit Suksamrarn
Srinakharinwirot University
Mahidol University
Ramkhamhaeng University
Chulabhorn Research Institute
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jun-2011
Citation: Phytochemistry. Vol.72, No.9 (2011), 909-915
Abstract: Investigation of the MeOH extract obtained from the root of the Ziziphus mauritiana grown in Thailand resulted in the isolation of two 14- and 13-membered cyclic alkaloids, mauritine L (1) and mauritine M (2), and three known cyclopeptide alkaloids, nummularines H (3), B (4) and hemsine A (5). Their structures were elucidated on the basis of extensive NMR spectroscopic analysis. The first single crystal X-ray diffraction study of the 13-membered ring cyclopeptide, nummularine B methiodide (4′), revealed all S configurations on the amino acid residues. The isolated alkaloids exhibited potent antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC 50 ) ranging from 3.7 to 10.3 μM. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 μM, respectively. © 2011 Elsevier Ltd. All rights reserved.
ISSN: 00319422
Appears in Collections:Scopus 2011-2015

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