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dc.contributor.authorSurawat Jariyawaten_US
dc.contributor.authorThanapol Thammapratipen_US
dc.contributor.authorKanoknetr Suksenen_US
dc.contributor.authorPodchanart Wanitchakoolen_US
dc.contributor.authorJintapat Nateewattanaen_US
dc.contributor.authorArthit Chairoungduaen_US
dc.contributor.authorApichart Suksamrarnen_US
dc.contributor.authorPawinee Piyachaturawaten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.identifier.citationCell Biology and Toxicology. Vol.27, No.6 (2011), 413-423en_US
dc.description.abstractDiarylheptanoids, isolated from the rhizome of Curcuma comosa Roxb., have several biological activities including anti-oxidant and anti-inflammation. The present study investigated the effect of five diarylheptanoids isolated from C. comosa rhizome on the proliferation of murine P388 leukemic cells. Compound-092, (3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol, bearing a catechol moiety, was the most potent diarylheptanoid (IC 50 of 4 μM) in inhibiting P388 leukemic cell viability by causing DNA breakage and inducing apoptosis. Apoptotic cell death was characterized by the presence of chromatin condensation, formation of apoptotic bodies, DNA fragmentation, and externalization of plasma membrane phosphatidylserine. This compound increased caspase-3 activity about fivefold above the untreated control, decreased the intracellular reduced glutathione level, and impaired mitochondrial transmembrane potential. In the presence of Cu(II) ion, the compound exhibited a pro-oxidant activity causing DNA strand breakage and enhancing the anti-proliferative activity. The results provide evidence for the pro-oxidant activity of the diarylheptanoid bearing a catechol moiety in the induction of apoptosis in murine P388 leukemia. © 2011 Springer Science+Business Media B.V.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectEnvironmental Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleInduction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb.en_US
Appears in Collections:Scopus 2011-2015

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