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Title: Beyond neurological disease: New targets for edaravone (Review)
Authors: Kiyoshi Kikuchi
Hisaaki Uchikado
Naohisa Miyagi
Yoko Morimoto
Ito Takashi
Salunya Tancharoen
Naoki Miura
Kie Miyata
Rokudai Sakamoto
Chiemi Kikuchi
Narumi Iida
Naoto Shiomi
Terukazu Kuramoto
K. Ichi Kawahara
Yame Public Hospital
Kurume University School of Medicine
Kagoshima University Faculty of Medicine
Mahidol University
Kagoshima University
Nishida Koutoku Hospital
Kohjin Co., Ltd.
Saiseikai Shiga Hospital
Omuta City General Hospital
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Dec-2011
Citation: International Journal of Molecular Medicine. Vol.28, No.6 (2011), 899-906
Abstract: Free radicals play major roles in the pathogenesis of tissue damage in many diseases and clinical conditions, and the removal of free radicals may offer a treatment option. Several modulators of free radical scavenger pathways have been developed and some have progressed to clinical trials. One such agent, edaravone, was approved in 2001 in Japan for the treatment of cerebral infarction. It has since been shown that edaravone can diffuse into many organs and, in addition to its effects on hydroxyl radical removal, edaravone modulates inflammatory processes, matrix metalloproteinase levels, nitric oxide production, apoptotic cell death, and necrotic cell death. Edaravone also exerts protective effects in a number of animal models of disease and tissue damage, including models of myocardial, lung, intestinal, liver, pancreatic and renal injury. Together with the proven safety of edaravone following 9 years of use as a modulator of free radical scavenging pathways in neurological disease, these additional effects of edaravone suggest that it may offer a novel treatment for several non-neurological diseases and clinical conditions in humans.
ISSN: 1791244X
Appears in Collections:Scopus 2011-2015

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