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Title: Simultaneous Determination of Artemether and Azithromycin in Suppositories by Reversed Phase HPLC
Authors: Karen Gaudin
Tina Kauss
Alexandra Gaubert
Vincent Viaud
Jean Pierre Dubost
Piero Olliaro
Nicholas J. White
Pascal Millet
Developpements Analytiques et Pharmaceutiques Appliques aux Maladies Negligees et Aux Contrefacons
Organisation Mondiale de la Sante
Nuffield Department of Clinical Medicine
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine
Issue Date: 1-Nov-2011
Citation: Analytical Letters. Vol.44, No.16 (2011), 2732-2743
Abstract: Chromatographic parameter assessments for RP-HPLC-UV method development for the simultaneous analysis of artemether and azithromycin for the pharmaceutical analysis of a rectal coformulation currently under development for the treatment of malaria infected children. Using methanol based mobile phase for the analysis of both artemether and azithromycin provided a more robust method in terms of resolution and peak symmetry. The method validated for suppository used 80% methanol and 20% phosphate buffer 15 mM at pH 9. The UV detection was at 210 nm. The accuracy profiles indicated a method validation between 80-120% for both active pharmaceutical ingredients. The preparation process of the suppository was validated based on theoretical values of artemether and azithromycin present in the formulation; active pharmaceutical ingredients were homogenously distributed within the suppository. © 2011 Copyright Taylor and Francis Group, LLC.
ISSN: 1532236X
Appears in Collections:Scopus 2011-2015

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