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|Title:||Simultaneous Determination of Artemether and Azithromycin in Suppositories by Reversed Phase HPLC|
Jean Pierre Dubost
Nicholas J. White
Developpements Analytiques et Pharmaceutiques Appliques aux Maladies Negligees et Aux Contrefacons
Organisation Mondiale de la Sante
Nuffield Department of Clinical Medicine
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine|
|Citation:||Analytical Letters. Vol.44, No.16 (2011), 2732-2743|
|Abstract:||Chromatographic parameter assessments for RP-HPLC-UV method development for the simultaneous analysis of artemether and azithromycin for the pharmaceutical analysis of a rectal coformulation currently under development for the treatment of malaria infected children. Using methanol based mobile phase for the analysis of both artemether and azithromycin provided a more robust method in terms of resolution and peak symmetry. The method validated for suppository used 80% methanol and 20% phosphate buffer 15 mM at pH 9. The UV detection was at 210 nm. The accuracy profiles indicated a method validation between 80-120% for both active pharmaceutical ingredients. The preparation process of the suppository was validated based on theoretical values of artemether and azithromycin present in the formulation; active pharmaceutical ingredients were homogenously distributed within the suppository. © 2011 Copyright Taylor and Francis Group, LLC.|
|Appears in Collections:||Scopus 2011-2015|
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