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dc.contributor.authorKaren Gaudinen_US
dc.contributor.authorTina Kaussen_US
dc.contributor.authorAlexandra Gauberten_US
dc.contributor.authorVincent Viauden_US
dc.contributor.authorJean Pierre Dubosten_US
dc.contributor.authorPiero Olliaroen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorPascal Milleten_US
dc.contributor.otherDeveloppements Analytiques et Pharmaceutiques Appliques aux Maladies Negligees et Aux Contrefaconsen_US
dc.contributor.otherOrganisation Mondiale de la Santeen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationAnalytical Letters. Vol.44, No.16 (2011), 2732-2743en_US
dc.description.abstractChromatographic parameter assessments for RP-HPLC-UV method development for the simultaneous analysis of artemether and azithromycin for the pharmaceutical analysis of a rectal coformulation currently under development for the treatment of malaria infected children. Using methanol based mobile phase for the analysis of both artemether and azithromycin provided a more robust method in terms of resolution and peak symmetry. The method validated for suppository used 80% methanol and 20% phosphate buffer 15 mM at pH 9. The UV detection was at 210 nm. The accuracy profiles indicated a method validation between 80-120% for both active pharmaceutical ingredients. The preparation process of the suppository was validated based on theoretical values of artemether and azithromycin present in the formulation; active pharmaceutical ingredients were homogenously distributed within the suppository. © 2011 Copyright Taylor and Francis Group, LLC.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleSimultaneous Determination of Artemether and Azithromycin in Suppositories by Reversed Phase HPLCen_US
Appears in Collections:Scopus 2011-2015

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