Please use this identifier to cite or link to this item:
http://repository.li.mahidol.ac.th/dspace/handle/123456789/11449
Title: | Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1 |
Authors: | Chiea Chuen Khor Tran Nguyen Bich Chau Junxiong Pang Sonia Davila Hoang Truong Long Rick T.H. Ong Sarah J. Dunstan Bridget Wills Jeremy Farrar Ta Van Tram Tran Thi Gan Nguyen Thi Nguyet Binh Le Trung Tri Le Bich Lien Nguyen Minh Tuan Nguyen Thi Hong Tham Mai Ngoc Lanh Nguyen Minh Nguyet Nguyen Trong Hieu Nguyen Van N Vinh Chau Tran Thi Thuy Dennis E.K. Tan Anavaj Sakuntabhai Yik Ying Teo Martin L. Hibberd Cameron P. Simmons Genome Institute of Singapore National University of Singapore Yong Loo Lin School of Medicine Oxford University Clinical Research Unit Nuffield Department of Clinical Medicine Tien Giang Hospital Sa Dec Hospital Children's Hospital No. 1 Dong Thap Hospital Hung Vuong Hospital UCL Children's Hospital No. 2 Institut Pasteur, Paris Mahidol University |
Keywords: | Biochemistry, Genetics and Molecular Biology |
Issue Date: | 1-Nov-2011 |
Citation: | Nature Genetics. Vol.43, No.11 (2011), 1139-1141 |
Abstract: | Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P meta = 4.41 × 10 -11 , per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P meta = 3.08 × 10 -10 , per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. © 2011 Nature America, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80055010567&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/11449 |
ISSN: | 15461718 10614036 |
Appears in Collections: | Scopus 2011-2015 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.