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Title: Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection
Authors: Stuart D. Blacksell
Ampai Tanganuchitcharnchai
Richard G. Jarman
Robert V. Gibbons
Daniel H. Paris
Mark S. Bailey
Nicholas P J Day
Ranjan Premaratna
David G. Lalloo
H. Janaka De Silva
Mahidol University
University of Oxford
Armed Forces Research Institute of Medical Sciences, Thailand
Royal Centre for Defence Medicine
University of Kelaniya
Liverpool School of Tropical Medicine
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2011
Citation: Clinical and Vaccine Immunology. Vol.18, No.10 (2011), 1773-1775
Abstract: A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
ISSN: 1556679X
Appears in Collections:Scopus 2011-2015

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