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Title: Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps
Authors: Jiahao Wu
Rattikan Chantiwas
Alborz Amirsadeghi
Steven A. Soper
Sunggook Park
Louisiana State University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Engineering
Issue Date: 7-Sep-2011
Citation: Lab on a Chip. Vol.11, No.17 (2011), 2984-2989
Abstract: Development of all polymer-based nanofluidic devices using replication technologies, which is a prerequisite for providing devices for a larger user base, is hampered by undesired substrate deformation associated with the replication of multi-scale structures. Therefore, most nanofluidic devices have been fabricated in glass-like substrates or in a polymer resist layer coated on a substrate. This letter presents a rapid, high fidelity direct imprinting process to build polymer nanofluidic devices in a single step. Undesired substrate deformation during imprinting was significantly reduced through the use of a polymer stamp made from a UV-curable resin. The integrity of the enclosed all polymer-based nanofluidic system was verified by a fluorescein filling experiment and translocation/stretching of λ-DNA molecules through the nanochannels. It was also found that the funnel-like design of the nanochannel inlet significantly improved the entrance of DNA molecules into nanochannels compared to an abrupt nanochannel/microfluidic network interface. © 2011 The Royal Society of Chemistry.
ISSN: 14730189
Appears in Collections:Scopus 2011-2015

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