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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/11496
Title: Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment
Authors: Preamrudee Poomthavorn
Ratchadaporn Suphasit
Pat Mahachoklertwattana
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Aug-2011
Citation: Gynecological Endocrinology. Vol.27, No.8 (2011), 524-528
Abstract: Background.?Long-term outcome data of central precocious puberty (CPP) girls treated with gonadotropin-releasing hormone analogue (GnRHa) are conflicting. Aim.?To assess long-term outcome of girls with idiopathic CPP (iCPP) treated with GnRHa Methods.?We compared adult height (AH), body mass index (BMI) and time of menarche in GnRHa-treated (n = 47) and untreated (n = 11) girls with iCPP. Results.?There were no differences in age, bone age, height, weight and BMI z-scores, predicted adult height (PAH) at the time of diagnosis and target height between the two groups. Mean (SD) age of GnRHa-treated girls was 8.5 (1.0) years at the start of treatment. Mean (SD) AH of the treated group was greater [158.6 (5.2) vs. 154.8 (5.6) cm], p < 0.05. AH gain over pre-treatment PAH in the treated group was 4.7 cm. BMI z-score of treated girls was 1.26 (0.95) before the treatment initiated and returned to normal [0.16 (1.0)] at the time of AH reached. Menstruation occurred at 0.9 (0.5) years following GnRHa discontinuation with regular pattern. Conclusions.?Long-term GnRHa therapy has a modest beneficial effect on adult height gain in girls with iCPP. No detrimental effects on increasing BMI and hypothalamicpituitarygonadal axis reactivation are demonstrated. © 2010 Informa UK, Ltd.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959931994&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/11496
ISSN: 14730766
09513590
Appears in Collections:Scopus 2011-2015

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