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dc.contributor.authorAmar Nagilaen_US
dc.contributor.authorJanjuree Netsawangen_US
dc.contributor.authorChatchawan Srisawaten_US
dc.contributor.authorSansanee Noisakranen_US
dc.contributor.authorAtthapan Morchangen_US
dc.contributor.authorUmpa Yasamuten_US
dc.contributor.authorChunya Puttikhunten_US
dc.contributor.authorWatchara Kasinrerken_US
dc.contributor.authorPrida Malasiten_US
dc.contributor.authorPa thai Yenchitsomanusen_US
dc.contributor.authorThawornchai Limjindapornen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherRangsit Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherChiang Mai Universityen_US
dc.identifier.citationBiochemical and Biophysical Research Communications. Vol.410, No.3 (2011), 428-433en_US
dc.description.abstractHepatic dysfunction is a well recognized feature of dengue virus (DENV) infection. However, molecular mechanisms of hepatic injury are still poorly understood. A complex interaction between DENV and the host immune response contributes to DENV-mediated tissue injury. DENV capsid protein (DENV C) physically interacts with the human death domain-associated protein Daxx. A double substitution mutation in DENV C (R85A/K86A) abrogates Daxx interaction, nuclear localization and apoptosis. Therefore we compared the expression of cell death genes between HepG2 cells expressing DENV C and DENV C (R85A/K86A) using a real-time PCR array. Expression of CD137, which is a membe r of the tumor necrosis factor receptor family, increased significantly in HepG2 cells expressing DENV C compared to HepG2 cells expressing DENV C (R85A/K86A). In addition, CD137-mediated apoptotic activity in HepG2 cells expressing DENV C was significantly increased by anti-CD137 antibody compared to that of HepG2 cells expressing DENV C (R85A/K86A). In DENV-infected HepG2 cells, CD137 mRNA and CD137 positive cells significantly increased and CD137-mediated apoptotic activity was increased by anti-CD137 antibody. This work is the first to demonstrate the contribution of CD137 signaling to DENV-mediated apoptosis. © 2011 Elsevier Inc.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleRole of CD137 signaling in dengue virus-mediated apoptosisen_US
Appears in Collections:Scopus 2011-2015

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