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|Title:||Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis|
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.74, No.6 (2011), 1386-1391|
|Abstract:||Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy.|
|Appears in Collections:||Scopus 2011-2015|
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