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Title: Antiplasmodial sesquiterpene alkaloids from the roots of maytenus mekongensis
Authors: Thitima Lhinhatrakool
Samran Prabpai
Palangpon Kongsaeree
Somyote Sutthivaiyakit
Ramkhamhaeng University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 24-Jun-2011
Citation: Journal of Natural Products. Vol.74, No.6 (2011), 1386-1391
Abstract: Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy.
ISSN: 15206025
Appears in Collections:Scopus 2011-2015

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