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Title: Radical scavenging and antioxidnt activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.
Authors: Kamolchanok Tianpanich
Surasak Prachya
Suthep Wiyakrutta
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Center for Environmental Health
Chulabhorn Research Institute
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-Jan-2011
Citation: Journal of Natural Products. Vol.74, No.1 (2011), 79-81
Abstract: Five known isocoumarins, monocerin (1), derivative 2, and fusarentin derivatives 3-5, and a new phthalide (6) were isolated from the endophytic fungus Colletotrichum sp. 2 selectively exhibited cytotoxic activity toward the HepG2 cell line. Compounds 2 and 4 scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals (IC50 values of 23.4 and 16.4 μM, respectively) and inhibited superoxide anion radical formation (IC50 values of 52.6 and 4.3 μM, respectively). The C-7 hydroxyl group in 2 and 4 might be important for radical scavenging activities. Isocoumarins 1-3 and phthalide 6 showed p otent antioxidant activity. © 2011 American Chemical Society and American Society of Pharmacognosy.
ISSN: 15206025
Appears in Collections:Scopus 2011-2015

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