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dc.contributor.authorCheepsumon Suthipintawongen_US
dc.contributor.authorSumalee Siriaunkgulen_US
dc.contributor.authorKobkul Tungsinmunkongen_US
dc.contributor.authorChamsai Pientongen_US
dc.contributor.authorTipaya Ekalaksanananen_US
dc.contributor.authorAnant Karalaken_US
dc.contributor.authorPilaiwan Kleebkaowen_US
dc.contributor.authorSongkhun Vinyuvaten_US
dc.contributor.authorSurang Triratanachaten_US
dc.contributor.authorSurapan Khunamornpongen_US
dc.contributor.authorTuenjai Chongsuwanichen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherRajavithi Hospitalen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-05-03T08:05:09Z-
dc.date.available2018-05-03T08:05:09Z-
dc.date.issued2011-01-01en_US
dc.identifier.citationAsian Pacific Journal of Cancer Prevention. Vol.12, No.4 (2011), 853-856en_US
dc.identifier.issn2476762Xen_US
dc.identifier.issn15137368en_US
dc.identifier.other2-s2.0-84856284999en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856284999&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/11642-
dc.description.abstractBackground: The pattern of infection in cervical lesions with respect to HPV subtype has not been systematically studied in Thai women. The aim here was to determine HPV prevalence, genotype, and infection pattern in cervical lesions and to estimate the potential efficacy of an HPV prophylactic vaccine. Design: Formalinfixed paraffin-embedded cervical tissue blocks of 410 Thai patients from 8 institutes in 4 regions of Thailand (northern, southern, north-eastern, and central) were studied. The samples included 169 low grade squamous intraepithelial lesions (LSILs), 121 high grade squamous intraepithelial lesions (HSILs), and 120 squamous cell carcinomas (SCCs). HPV-DNA was amplified by PCR using consensus primers GP5+ and GP6+. The HPV genotype was then determined by reverse linear blot assay that included 37 HPV-specific 5'-amino-linked oligonucleotide probes. Patterns of infection were classified as single infection (one HPV type), double infection (two HPV types), and multiple infection (three or more HPV types). Results: The mean age of the subjects was 42 years. The prevalence of HPV infection was 88.8%. The highest HPV prevalence was found in the southern region (97.1%) and the lowest in the central region (78.6%). HPV-DNA was detected in 84.6% of LSILs, 90.1% of HSILs, and 93.3% of SCCs. A total of 20 HPV genotypes were identified. The five most common high risk HPV were HPV16 (83.2%), HPV18 (59.3%), HPV58 (9.3%), HPV52 (4.1%), and HPV45 (3.8%). In double and multiple infection patterns, the most common genotypes were HPV16/18 (27.8%) and HPV11/16/18 (54.9%). HPV6 was found only in LSIL and never in combination with other subtypes. HPV11 was most common in LSIL. Conclusion: There is no difference of HPV type distribution in women from 4 regions of Thailand with prominent HPV16 and HPV18 in all cases. The bivalent and quadrivalent vaccines have the potential to prevent 48.6 % and 74.5% of cervical cancers in Thai women. The potential of cancer prevention would rise to 87.6% if other frequent HR-HPV types (HPV58, 52, and 45) were also targeted by an HPV vaccine.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856284999&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleHuman papilloma virus prevalence, genotype distribution, and pattern of infection in Thai womenen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
Appears in Collections:Scopus 2011-2015

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