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Title: PEG-b-PCL and PEG-b-PLA polymeric micelles as nanocarrieres for lamellarin N delivery
Authors: Hathaichanok Pungkham
Nattharin Swatdipakdi
Man Theerasilp
Supattra Karnkla
Montakarn Chittchang
Poonsakdi Ploypradith
Norased Nasongkla
Mahidol University
Chulabhorn Research Institute
Keywords: Computer Science;Engineering;Medicine
Issue Date: 26-Dec-2011
Citation: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. (2011), 3245-3248
Abstract: Lamellarin N (Lam N) is a member of an interesting marine natural product class isolated from mollusks and subsequently found in ascidians and sponges. The limited aqueous solubility of Lam N hinders further studies on its cytotoxic activity against cancer cells. In this study, micelles comprising poly(ethylene glycol)-block-poly(-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(D, L-lactide) (PEG-b-PLA) were developed to circumvent Lam N limited aqueous solubility. The results showed that an increase in the molecular weight of both core materials resulted in higher Lam N loading content, whereas the release of Lam N decreased as a function of molecular weight of PCL and PLA. With less hydrophobic property, PLA micelles provided faster Lam N release. Thus, polymeric micelles could be utilized as controlled-release delivery systems for poorly water soluble Lam N. © 2011 IEEE.
ISSN: 1557170X
Appears in Collections:Scopus 2011-2015

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