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dc.contributor.authorThinnakorn Permpongpaiboonen_US
dc.contributor.authorAmar Nagilaen_US
dc.contributor.authorPhannee Pidetchaen_US
dc.contributor.authorKulwadee Tuangmungsakulchaien_US
dc.contributor.authorSoontharee Tantrarongrojen_US
dc.contributor.authorSureerut Porntadavityen_US
dc.contributor.otherFaculty of Medical Technologyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFishtail Hospitalen_US
dc.date.accessioned2018-05-03T08:12:38Z-
dc.date.available2018-05-03T08:12:38Z-
dc.date.issued2011-09-01en_US
dc.identifier.citationHuman and Experimental Toxicology. Vol.30, No.9 (2011), 1196-1203en_US
dc.identifier.issn14770903en_US
dc.identifier.issn09603271en_US
dc.identifier.other2-s2.0-79960111371en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960111371&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/11916-
dc.description.abstractParaoxonase 1 (PON1) has been proposed as an antioxidant enzyme. Although lead-inhibited PON1 activity has been demonstrated mostly based on in vitro experiments, it is uncertain whether this phenomenon is relevant in pathogenesis of lead-induced oxidative stress in the lead exposure. We examined associations of blood lead levels (BLL) and PON1 activity along with oxidative stress parameters in lead exposure workers. We determined malondialdehyde (MDA), conjugated diene (CD), total peroxides (TP), total antioxidant status (TAS), the oxidative stress index (OSI), and PON1 activity in earthenware factory workers (n = 60) and control subjects (n = 65). The lead-exposed group significantly increased lipid peroxidation parameters and OSI compared to the control group (p < 0.001). The lead-exposed group had significantly decreased PON1 activity and TAS levels compared to the control group (p < 0.001). Multiple linear regression analysis revealed that BLL were significantly correlated with decreased TAS (r = -0.496) and PON1 activity (r = -0.434), but with increased CD (r = 0.694), TP (r = 0.614), MDA (r = 0.788), and OSI (r = 0.722). Interestingly, BLL at 10 μg/dL significantly decreased PON1 activity and increased oxidative stress parameters with insignificant changes in other biochemical and hematological parameters. Altogether, the reduction of PON1 activity may associate in an imbalance in pro-oxidants and antioxidants, leading to oxidative damage in lead-exposed workers even at low BLL. © 2011 SAGE Publications.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960111371&origin=inwarden_US
dc.subjectEnvironmental Scienceen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDecreased paraoxonase 1 activity and increased oxidative stress in low lead-exposed workersen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1177/0960327110388536en_US
Appears in Collections:Scopus 2011-2015

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