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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/11932
Title: The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentration in Thai bus drivers
Authors: Krittaya Petchpoung
Sming Kaojarern
Krongtong Yoovathaworn
Thanyachai Sura
Jintana Sirivarasai
Mahidol University
Keywords: Environmental Science;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2011
Citation: Environmental Toxicology and Pharmacology. Vol.31, No.1 (2011), 160-164
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are associated with an increased cancer risk. CYP1A1 and GSTs enzymes are important in metabolism of PAHs. Genetic polymorphisms of these enzymes are responsible for enzyme activity and concentration variation. The objectives of this study were to evaluate association of 1-OHP concentration with genetic polymorphisms of CYP1A1and GSTs in Thai bus drivers. The results showed that 1-OHP levels in bus drivers were significantly higher than that in the control group. Significant difference in 1-OHP was found between smokers and non-smokers, in only bus drivers. Significantly increasing of 1-OHP levels were observed in bus drivers with CYP1A1 MspI and exon 7 variants. Whereas, bus drivers with GSTP1 Val and GSTM1 null genotypes showed decreasing in excretion of 1-OHP. No association between 1-OHP and polymorphisms of GSTT1 was found. This study indicated that 1-OHP concentrations were associated with exposure to air pollution, cigarette smoking and polymorphisms of CYP1A1, GSTM1 and GSTP1 genes. © 2010 Elsevier B.V.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78650216205&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/11932
ISSN: 13826689
Appears in Collections:Scopus 2011-2015

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