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Title: Burkholderia pseudomallei-induced cell fusion in U937 macrophages can be inhibited by monoclonal antibodies against host cell surface molecules
Authors: Supaporn Suparak
Veerachat Muangsombut
Donporn Riyapa
Joanne M. Stevens
Mark P. Stevens
Ganjana Lertmemongkolchai
Sunee Korbsrisate
Mahidol University
Khon Kaen University
University of Edinburgh, Roslin Institute
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2011
Citation: Microbes and Infection. Vol.13, No.12-13 (2011), 1006-1011
Abstract: Burkholderia pseudomallei induces the formation of multinucleated giant cells in cell monolayers. After infection of human macrophage-like U937 cells with B. pseudomallei, addition of monoclonal antibodies against integrin-associated protein (CD47), E-selectin (CD62E), a fusion regulatory protein (CD98), and E-cadherin (CD324) suppressed multinucleated giant cells in a concentration-dependent manner while monoclonal antibodies against other surface molecules did not inhibit fusion despite binding to the cell surface. Flow cytometric analysis showed increased expression of CD47 and CD98, but not CD62E and CD324, upon B. pseudomallei infection. Our data suggest the involvement of specific cellular factors in the process of B. pseudomallei-induced fusion. © 2011 Institut Pasteur.
ISSN: 1769714X
Appears in Collections:Scopus 2011-2015

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