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Title: Induced autophagy reduces virus output in dengue infected monocytic cells
Authors: Mingkwan Panyasrivanit
Michael P. Greenwood
David Murphy
Ciro Isidoro
Prasert Auewarakul
Duncan R. Smith
Mahidol University
University of Bristol
Universita degli Studi del Piemonte Orientale Amedeo Avogadro
Keywords: Immunology and Microbiology
Issue Date: 15-Sep-2011
Citation: Virology. Vol.418, No.1 (2011), 74-84
Abstract: While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susceptible to antibody enhanced infection. This study sought to determine the involvement of autophagy in the DENV infection of monocytic cells, using U937 cells as a model system. While the induction of autophagy was seen in response to DENV-2 infection, biochemical induction of autophagy resulted in a significant decrease in virus output. Down regulation of autophagy resulted in only a very slight increase in intracellular virus levels. In monocytic cells autophagy is not a significant part of the DENV replication mechanism, and there are distinct cell type specific differences in the DENV-autophagy interaction. © 2011 Elsevier Inc.
ISSN: 10960341
Appears in Collections:Scopus 2011-2015

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