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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12005
Title: Leptospirosis outbreak in Sri Lanka in 2008: Lessons for assessing the global burden of disease
Authors: Suneth B. Agampodi
Sharon J. Peacock
Vasanthi Thevanesam
Danaseela B. Nugegoda
Lee Smythe
Janjira Thaipadungpanit
Scott B. Craig
Mary Ann Burns
Michael Dohnt
Siriphan Boonsilp
Thamarasi Senaratne
Athula Kumara
Paba Palihawadana
Sahan Perera
Joseph M. Vinetz
University of Colombo
University of California, San Diego, School of Medicine
Mahidol University
University of Cambridge
University of Peradeniya
Organisation Mondiale de la Sante
University of the Sunshine Coast
Ministry of Health Colombo
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2011
Citation: American Journal of Tropical Medicine and Hygiene. Vol.85, No.3 (2011), 471-478
Abstract: Global leptospirosis disease burden estimates are hampered by the lack of scientifically sound data from countries with probable high endemicity and limited diagnostic capacities. We describe the seroepidemiologic and clinical characteristics of the leptospirosis outbreak in 2008 in Sri Lanka. Definitive/presumptive case definitions proposed by the World Health Organization Leptospirosis Epidemiology Reference Group were used for case confirmation. Of the 404 possible cases, 155 were confirmed to have leptospirosis. Highest titers of patient seum samples reacted with serovars Pyrogenes (28.7%), Hardjo (18.8%), Javanica (11.5%), and Hebdomadis (11.5%). Sequencing of the 16S ribosomal DNA gene identified six infections: five with Leptospira interrogans and one with L. weilli. In this patient population, acute renal failure was the main complication (14.8%), followed by myocarditis (7.1%) and heart failure (3.9%). The case-fatality rate was 1.3%. This report strengthens the urgent need for increasing laboratory diagnostic capabilities to determine the causes of epidemic and endemic infectious diseases in Sri Lanka, a finding relevant to other tropical regions. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052813834&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12005
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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