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dc.contributor.authorLeoneide Érica Maduro Bouilleten_US
dc.contributor.authorMariana Oliveira Diasen_US
dc.contributor.authorNatália Alves Dorigoen_US
dc.contributor.authorAndrew Douglas Mouraen_US
dc.contributor.authorBruce Russellen_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorLaurent Reniaen_US
dc.contributor.authorÉrika Martins Bragaen_US
dc.contributor.authorRicardo Tostes Gazzinellien_US
dc.contributor.authorMaurício M. Rodriguesen_US
dc.contributor.authorIrene S. Soaresen_US
dc.contributor.authorOscar Bruna-Romeroen_US
dc.contributor.otherUniversidade Federal de Minas Geraisen_US
dc.contributor.otherUniversidade de Sao Paulo - USPen_US
dc.contributor.otherUniversidade Federal de Sao Pauloen_US
dc.contributor.otherFundacao Oswaldo Cruzen_US
dc.contributor.otherAgency for Science, Technology and Research, Singaporeen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherChurchill Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationInfection and Immunity. Vol.79, No.9 (2011), 3642-3652en_US
dc.description.abstractApical membrane antigen 1 (AMA-1) is an invasion-related Plasmodium antigen that is expressed during both intracellular and extracellular asexual stages of the parasite's life cycle, making it an ideal target for induction of humoral and cellular immune responses that can protect against malaria. We show here that when it is administered as a recombinant protein (P) in Montanide ISA720 adjuvant, followed by a recombinant human type 5 adenovirus (Ad), intense and long-lasting Plasmodium vivax AMA-1-specific antibody responses (including both IgG1 and IgG2a), as well as proliferative memory T cell responses, can be detected in immunized mice. Memory T cells displayed both central (CD44 hi CD62L hi ) and effector (CD44 hi CD62L lo ) phenotypes, with the central memory phenotype prevailing (56% of AMA-1-specific proliferating cells). Considering the main traits of the memory immune responses induced against AMA-1, this particular sequence of immunogens (P followed by Ad), but no others (Ad/Ad, Ad/P, or P/P), displayed an optimal synergistic effect. These results give further support to the need for preclinical studies of P. vivax vaccine candidate AMA-1 administered in prime/boost protocols that include recombinant proteins and adenoviral vectors. © 2011, American Society for Microbiology.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleLong-term humoral and cellular immune responses elicited by a heterologous Plasmodium vivax apical membrane antigen 1 protein prime/adenovirus boost immunization protocolen_US
Appears in Collections:Scopus 2011-2015

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