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Title: In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China
Authors: Feng Lu
Qi Gao
Kesinee Chotivanich
Hui Xia
Jun Cao
Rachanee Udomsangpetch
Liwang Cui
Jetsumon Sattabongkot
Jiangsu Institute of Parasitic Diseases
Mahidol University
Bengbu Medical College
Pennsylvania State University
Armed Forces Research Institute of Medical Sciences, Thailand
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2011
Citation: American Journal of Tropical Medicine and Hygiene. Vol.85, No.2 (2011), 197-201
Abstract: In the face of recent increase of Plasmodium vivax malaria in central China, we conducted a study to evaluate in vitro susceptibility of temperate-zone P. vivax parasites to antimalarial drugs. During 2005-2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (IC50s) and 95% confidence intervals (CIs) were 10.87 (4.50-26.26) ng/mL for chloroquine, 4.21 (1.88-9.42-8) ng/mL for mefloquine, 11.82 (6.20-22.56) ng/mL for quinine, 0.13 (0.09-0.20) ng/mL for artesunate, 18.32 (8.08-41.50) ng/mL for pyrimethamine, and 17.73 (10.29-30.57) ng/mL for piperaquine. The IC50for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against P. vivax malaria in central China. The results further indicated that temperate-zone P. vivax isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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