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dc.contributor.authorNada Pitabuten_US
dc.contributor.authorSurakameth Mahasirimongkolen_US
dc.contributor.authorHideki Yanaien_US
dc.contributor.authorChutharut Ridruechaien_US
dc.contributor.authorShinsaku Sakuradaen_US
dc.contributor.authorPanadda Dhepaksonen_US
dc.contributor.authorPacharee Kantipongen_US
dc.contributor.authorSurachai Piyaworawongen_US
dc.contributor.authorSaiyud Moolphateen_US
dc.contributor.authorChamnarn Hansudewechakulen_US
dc.contributor.authorNorio Yamadaen_US
dc.contributor.authorNaoto Keichoen_US
dc.contributor.authorMasaji Okadaen_US
dc.contributor.authorSrisin Khusmithen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherJapan Anti-Tuberculosis Associationen_US
dc.contributor.otherNational Center Global Health and Medicineen_US
dc.contributor.otherChiang Rai Prachanukhro Hospitalen_US
dc.contributor.otherMae Chan Hospitalen_US
dc.contributor.otherChiang Rai Provincial Health Officeen_US
dc.contributor.otherThe Research Institute of Tuberculosis, Japan Anti-Tuberculosis Associationen_US
dc.contributor.otherNational Hospital Organization, Japanen_US
dc.identifier.citationMicrobiology and Immunology. Vol.55, No.8 (2011), 565-573en_US
dc.description.abstractGranulysin and interferon-gamma (IFN-γ) have broad antimicrobial activity which controls Mycobacterium tuberculosis (M. tuberculosis) infection. Circulating granulysin and IFN-γ concentrations were measured and correlated with clinical disease in Thai patients with newly diagnosed, relapsed and chronic tuberculosis (TB). Compared to controls, patients with newly diagnosed, relapsed and chronic TB had lower circulating granulysin concentrations, these differences being significant only in newly diagnosed and relapsed TB (P < 0.001 and 0.004, respectively). Granulysin concentrations in patients with newly diagnosed and relapsed TB were significantly lower than in those with chronic TB (P= 0.003 and P= 0.022, respectively). In contrast, significantly higher circulating IFN-γ concentrations were found in patients with newly diagnosed and relapsed TB compared to controls (P < 0.001). The IFN-γ concentrations in newly diagnosed and relapsed patients were not significantly different from those of patients with chronic TB. However, in vitro stimulation of peripheral blood mononuclear cells (PBMCs) from patients with newly diagnosed, relapsed and chronic TB with purified protein derivative (PPD) or heat killed M. tuberculosis (H37Ra) enhanced production of granulysin by PBMCs. In vitro, stimulation of PBMCs of newly diagnosed TB patients with PPD produced greater amounts of IFN-γ than did controls, while those stimulated with H37Ra did not. The results demonstrate that patients with active pulmonary TB have low circulating granulysin but high IFN-γ concentrations, suggesting possible roles in host defense against M. tuberculosis for these agents. © 2011 The Societies and Blackwell Publishing Asia Pty Ltd.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleDecreased plasma granulysin and increased interferon-gamma concentrations in patients with newly diagnosed and relapsed tuberculosisen_US
Appears in Collections:Scopus 2011-2015

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