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Title: Short report: Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis
Authors: Direk Limmathurotsakul
Vanaporn Wuthiekanun
Gumphol Wongsuvan
Sukanya Pangmee
Premjit Amornchai
Prapit Teparrakkul
Nittaya Teerawattanasook
Nicholas P J Day
Sharon J. Peacock
Mahidol University
Sappasitthiprasong Hospital
University of Oxford
Nuffield Department of Clinical Medicine
University of Cambridge
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jun-2011
Citation: American Journal of Tropical Medicine and Hygiene. Vol.84, No.6 (2011), 858-861
Abstract: Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1-8.7, P < 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1-6.0, P = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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