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Title: Differential host gene responses in mice infected with two highly pathogenic avian influenza viruses of subtype H5N1 isolated from wild birds in Thailand
Authors: Tsuyoshi Hayashi
Kridsada Chaichoune
Tuangthong Patchimasiri
Yasuaki Hiromoto
Yuri Kawasaki
Witthawat Wiriyarat
Warunya Chakritbudsabong
Natanan Prayoonwong
Natnapat Chaisilp
Sujira Parchariyanon
Parntep Ratanakorn
Yuko Uchida
Tomoyuki Tsuda
Takehiko Saito
Thailand-Japan Zoonotic Diseases Collaboration Center
National Institute of Animal Health, NARO
Mahidol University
Thailand National Institute of Animal Health
Keywords: Immunology and Microbiology
Issue Date: 30-Mar-2011
Citation: Virology. Vol.412, No.1 (2011), 9-18
Abstract: In Thailand, highly pathogenic avian influenza (HPAI) viruses of subtype H5N1 had been isolated from various wild birds during the HPAI outbreak in poultries. In this study, we examined the pathogenicity of two wild bird isolates (A/Pigeon/Thailand/VSMU-7-NPT/2004; Pigeon04 and A/Tree sparrow/Ratchaburi/VSMU-16-RBR/2005; T.sparrow05) in mice. They showed similar replication in several organs and lethal outcome. However, on day 3 post-infection, Pigeon04 induced mRNA expression of proinflammatory cytokines (IL6 and TNFα) and MIP-2, neutrophil chemoattractant, in the lungs, resulting in severe pneumonia that was accompanied by neutrophil in filtration. In contrast, on day 7 post-infection, T.sparrow05 induced the expression of several cytokines to a greater extent than Pigeon04; it also potently induced mRNA expression of several cytokines in brains of the infected mice that triggered frequent inflammatory events. In sum, our study demonstrated that two HPAI viruses induced different host responses, despite having similar replications, resulting in lethal outcome in mice. © 2010 Elsevier Inc.
ISSN: 10960341
Appears in Collections:Scopus 2011-2015

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