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Title: Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia
Authors: Emma K. Nickerson
Vanaporn Wuthiekanun
Varun Kumar
Premjit Amornchai
Nattavut Wongdeethai
Kheng Chheng
Narisara Chantratita
Hor Putchhat
Janjira Thaipadungpanit
Nicholas P. Day
Sharon J. Peacock
Addenbrooke's Hospital
Mahidol University
Angkor Hospital for Children
University of Cambridge
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2011
Citation: American Journal of Tropical Medicine and Hygiene. Vol.84, No.2 (2011), 313-317
Abstract: We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia. We define the rate of pediatric MRSA carriage in the same population and characterize the associated bacterial genotypes by using pulsed-field gel electrophoresis and multilocus sequence typing. A prospective cohort study of MRSA carriage conducted over one month at the Angkor Hospital for Children, Siem Reap, Cambodia, identified MRSA carriage in 87 (3.5%) of 2,485 children who came to the outpatient department, and 6 (4.1%) of 145 inpatients, including at least two with cases of nosocomial acquisition. Genotyping of all 93 MRSA isolates resolved 5 genotypes. Most (91%) isolates were assigned to sequence type 834. Only 28 (32%) of 87 MRSA carriers identified in the outpatient department had no history of recent healthcare contact. The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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