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Title: Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells
Authors: Sineewanlaya Wichit
Akanitt Jittmittraphap
Kazuya I.P.J. Hidari
Butsaya Thaisomboonsuk
Songsak Petmitr
Sukathida Ubol
Chie Aoki
Saki Itonori
Koichi Morita
Takashi Suzuki
Yasuo Suzuki
Wipawee Jampangern
Mahidol University
Armed Forces Research Institute of Medical Sciences, San Francisco
University of Shizuoka
Shiga University
Nagasaki University
Chubu University
University of Tokyo
Keywords: Immunology and Microbiology
Issue Date: 1-Feb-2011
Citation: Microbiology and Immunology. Vol.55, No.2 (2011), 135-140
Abstract: Dengue viruses infect cells by attaching to a surface receptor which remains unknown. The putative receptor molecules of dengue virus type 2 on the surface of mosquito (AP-61) and mammalian (LLC-MK2) cell lines were investigated. The immunochemical detection and structural analysis of carbohydrates demonstrated that the neutral glycosphingolipids, L-3 (GlcNAcβ1-3Manβ1-4Glcβ1-1'Cer) in AP-61 cells, and nLc 4 Cer (Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1'Cer) in LLC-MK2 cells were recognized by the virus. These findings strongly suggest that neutral glycosphingolipids share the key determinant for virus binding and that the β-GlcNAc residue may play an important role in dengue virus binding to the host cell surface. © 2011 The Societies and Blackwell Publishing Asia Pty Ltd.
ISSN: 13480421
Appears in Collections:Scopus 2011-2015

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