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|Title:||Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells|
Kazuya I.P.J. Hidari
Armed Forces Research Institute of Medical Sciences, San Francisco
University of Shizuoka
University of Tokyo
|Keywords:||Immunology and Microbiology|
|Citation:||Microbiology and Immunology. Vol.55, No.2 (2011), 135-140|
|Abstract:||Dengue viruses infect cells by attaching to a surface receptor which remains unknown. The putative receptor molecules of dengue virus type 2 on the surface of mosquito (AP-61) and mammalian (LLC-MK2) cell lines were investigated. The immunochemical detection and structural analysis of carbohydrates demonstrated that the neutral glycosphingolipids, L-3 (GlcNAcβ1-3Manβ1-4Glcβ1-1'Cer) in AP-61 cells, and nLc 4 Cer (Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1'Cer) in LLC-MK2 cells were recognized by the virus. These findings strongly suggest that neutral glycosphingolipids share the key determinant for virus binding and that the β-GlcNAc residue may play an important role in dengue virus binding to the host cell surface. © 2011 The Societies and Blackwell Publishing Asia Pty Ltd.|
|Appears in Collections:||Scopus 2011-2015|
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