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Title: Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity
Authors: Thararat Nualsanit
Pleumchitt Rojanapanthu
Wandee Gritsanapan
Thiwanporn Kwankitpraniti
Kyung Won Min
Seung Joon Baek
University of Tennessee College of Veterinary Medicine
Mahidol University
Thailand Ministry of Public Health
Keywords: Immunology and Microbiology;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2011
Citation: Inflammation and Allergy - Drug Targets. Vol.10, No.6 (2011), 455-463
Abstract: Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this anti-inflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-KB (NF-kB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases. © 2011 Bentham Science Publishers.
ISSN: 18715281
Appears in Collections:Scopus 2011-2015

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