Please use this identifier to cite or link to this item:
|Title:||Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity|
Kyung Won Min
Seung Joon Baek
University of Tennessee College of Veterinary Medicine
Thailand Ministry of Public Health
|Keywords:||Immunology and Microbiology;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Inflammation and Allergy - Drug Targets. Vol.10, No.6 (2011), 455-463|
|Abstract:||Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this anti-inflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-KB (NF-kB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases. © 2011 Bentham Science Publishers.|
|Appears in Collections:||Scopus 2011-2015|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.