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Title: Biomagnetic of Apatite-Coated Cobalt Ferrite: A Core-Shell Particle for Protein Adsorption and pH-Controlled Release
Authors: I. Ming Tang
Nateetip Krishnamra
Narattaphol Charoenphandhu
Rassmidara Hoonsawat
Weeraphat Pon-On
Commission of Higher Education
Mahidol University
Keywords: Materials Science;Physics and Astronomy
Issue Date: 1-Jan-2011
Citation: Nanoscale Research Letters. Vol.6, No.1 (2011), 1-10
Abstract: Magnetic nanoparticle composite with a cobalt ferrite (CoFe 2 O 4 , (CF)) core and an apatite (Ap) coating was synthesized using a biomineralization process in which a modified simulated body fluid (1.5SBF) solution is the source of the calcium phosphate for the apatite formation. The core-shell structure formed after the citric acid-stabilized cobalt ferrite (CFCA) particles were incubated in the 1.5 SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of 15.56 emug -1 and a coercivity of 1808.5 Oe were observed for the CFCA-Ap obtained. Bovine serum albumin (BSA) was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution, thus indicating that the BSA release is dependent on the local pH. © 2010 The Author(s).
ISSN: 1556276X
Appears in Collections:Scopus 2011-2015

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