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Title: Effect of systemic antibiotics and topical chlorhexidine on meticillin-resistant Staphylococcus aureus carriage in intensive care unit patients
Authors: T. Kypraios
P. D. O'Neill
D. E. Jones
J. Ware
R. Batra
J. D. Edgeworth
B. S. Cooper
University of Nottingham
Guy's and St Thomas' NHS Foundation Trust
King's College London
Nuffield Department of Clinical Medicine
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2011
Citation: Journal of Hospital Infection. Vol.79, No.3 (2011), 222-226
Abstract: Antibiotics and antiseptics have the potential to influence carriage and transmission of meticillin-resistant Staphylococcus aureus (MRSA), although effects are likely to be complex, particularly in a setting where multiple agents are used. Here admission and weekly MRSA screens and daily antibiotic and antiseptic prescribing data from 544 MRSA carriers on an intensive care unit (ICU) are used to determine the effect of these agents on short-term within-host MRSA carriage dynamics. Longitudinal data were analysed using Markov models allowing patients to move between two states: MRSA positive (detectable MRSA carriage) and MRSA negative (no detectable carriage). The effect of concurrent systemic antibiotic and topical chlorhexidine (CHX) on movement between these states was assessed. CHX targeted to MRSA screen carriage sites increased transition from culture positive to negative and there was also weaker evidence that it decreased subsequent transition from negative back to positive. In contrast, there was only weak and inconsistent evidence that any antibiotic influenced transition in either direction. For example, whereas univariate analysis found quinolones to be strongly associated with both increased risk of losing and then reacquiring MRSA carriage over time intervals of one day, no effect was seen with weekly models. Similar studies are required to determine the generalisability of these findings. © 2011 The Healthcare Infection Society.
ISSN: 15322939
Appears in Collections:Scopus 2011-2015

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