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dc.contributor.authorKasama Sukapiromen_US
dc.contributor.authorNattawat Onlamoonen_US
dc.contributor.authorCharin Thepthaien_US
dc.contributor.authorKorakot Polsrilaen_US
dc.contributor.authorBoonrat Tassaneetrithepen_US
dc.contributor.authorKovit Pattanapanyasaten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-05-03T08:24:38Z-
dc.date.available2018-05-03T08:24:38Z-
dc.date.issued2011-10-01en_US
dc.identifier.citationJournal of Acquired Immune Deficiency Syndromes. Vol.58, No.2 (2011), 141-147en_US
dc.identifier.issn10779450en_US
dc.identifier.issn15254135en_US
dc.identifier.other2-s2.0-80052966207en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052966207&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/12272-
dc.description.abstractBackground: Enumeration of CD4+ T-lymphocytes is important in the management of HIV. However, standard laboratory systems based on flow cytometry are expensive, complicated, and thus unavailable to most resource-limited settings where a low-cost and fully automated point-of-care CD4 testing system is required. In attempts to address this issue, a study was conducted to validate the Alere PIMA point-of-care CD4 test. Method: Duplicate values of the absolute number of CD4+ T-lymphocytes in 203 HIV-infected blood samples obtained using the PIMA system were compared with the two predicate single-platform FACSCount and the dual-platform FACSCan (Becton Dickinson Biosciences). RESULTS:: The overall absolute CD4+ T-lymphocyte count obtained using the PIMA system correlated highly with the FACSCount (r 2 = 0.957; mean bias,-54.2 cells/μL; limit of agreement,-190.9 to +82.5 cells/μL) and the FACSCan (r 2 = 0.957; mean bias-44.0 cells/μL; limit of agreement,-179.7 to +91.6 cells/μL). Good correlation and low biases were also observed for samples with CD4+ T-lymphocyte count ranges of 0 to 200 and 0 to 350 cells/μL. Additionally, there was no significant difference in absolute CD4+ T-lymphocyte counts noted between the duplicate samples using the PIMA system. Conclusions: This new point-of-care product is a simple and reliable system and should contribute significantly to the simplification of performing CD4 testing and thus increase access for patients in resource-limited settings. The inability to obtain values for the frequency (%) of CD4+ T-lymphocyte count is one limitation of the PIMA system, the addition of which would be of value for clinical staging or monitoring in HIV-infected pediatric patients. © 2011 by Lippincott Williams & Wilkins.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052966207&origin=inwarden_US
dc.subjectMedicineen_US
dc.titlePerformance evaluation of the alere PIMA CD4 test for monitoring HIV-infected individuals in resource-constrained settingsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1097/QAI.0b013e31822866a2en_US
Appears in Collections:Scopus 2011-2015

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