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Title: Pandemic (H1N1) 2009 virus infection: Persistent viral shedding after Oseltamivir treatment
Authors: Sawan Kanchana
Supannakhon Kanchana
Charas Chuntrakul
Kumthorn Malathum
Slinporn Prachayangprecha
Yong Poovorawan
Thungsong Hospital
Mahidol University
Chulalongkorn University
Keywords: Medicine
Issue Date: 1-Oct-2011
Citation: Journal of Infection. Vol.63, No.4 (2011), 295-299
Abstract: Objectives: To study pandemic (H1N1) 2009 virological outcomes after Oseltamivir treatment in confirmed cases of pandemic (H1N1) 2009 virus infections. A hospital-based cohort study was conducted in south Thailand, between June and September 2009. Methods: Throat/swab specimens were tested by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) for pandemic (H1N1) 2009. All 357 confirmed cases (122 inpatients, 235 outpatients), whose received a 5-day Oseltamivir treatment. Post-treatment virological follow-up was performed in 91 eligible cases. The NA gene was screened for the H275Y mutation responsible for Oseltamivir resistance. Results: Thirty-three of 91 patients (36%) had underlying diseases. The duration from the onset of illness to the detection of virus ranged 1-14 days (median 3 days). The rRT-PCR was positive on day 5 of treatment in 24 of 91 patients (26%). Patients with underlying diseases had a higher proportion of post-treatment positive test than those without underlying diseases (15/33 vs 9/58). The rRT-PCR-confirmed viruses detected in all 125 throat swab specimens did not show evidence suggesting Oseltamivir resistance. Conclusions: Prolonged presence of pandemic (H1N1) 2009 detected by rRT-PCR was found. An extended course of antiviral treatment should be considered in patients with underlying diseases and severe clinical symptoms. © 2011 The British Infection Association.
ISSN: 15322742
Appears in Collections:Scopus 2011-2015

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