Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12314
Title: Comparison of staging systems of hepatocellular carcinoma
Authors: Yongyut Sirivatanauksorn
Chutwichai Tovikkai
Mahidol University
Keywords: Medicine
Issue Date: 16-Sep-2011
Citation: HPB Surgery. Vol.2011, (2011)
Abstract: Many staging systems of hepatocellular carcinoma (HCC) were established; however, there is no consensus on which is proper in predicting prognosis. This study aims to evaluate various commonly used staging systems of HCC. Patients who underwent surgery during 20012007 were included. All patient data were retrospectively staged using six staging systems, that are American Joint Committee on Cancer (AJCC) Tumour-Node-Metastasis (TNM), Okuda staging, Cancer of the Liver Italian Program (CLIP), Barcelona Clinic Liver Cancer (BCLC), Chinese University Prognostic Index (CUPI), and Japan Integrated Staging (JIS). Child-Pugh classification was also evaluated. The staging systems were compared by mean of overall and disease-free survival. Total of 99 patient data were enrolled in the analyses. All staging systems except Okuda were significant in determining overall survival in univariate analyses. In multivariate analyses, TNM and Child-Pugh demonstrated better predictive power for overall survival. In terms of disease-free survival, univariate analyses revealed that TNM, CLIP, BCLC, CUPI, and JIS were significant, and TNM was the best predictive staging system in multivariate analyses. In our study, TNM and Child-Pugh are the representative systems in predicting survival of HCC patients who undergo surgical resection. Moreover, they are practical and easily assessable in clinical practice. Copyright 2011 Yongyut Sirivatanauksorn and Chutwichai Tovikkai.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052676062&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12314
ISSN: 16078462
08948569
Appears in Collections:Scopus 2011-2015

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