Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12361
Title: A small amount of fat does not affect piperaquine exposure in patients with malaria
Authors: Anna Annerberg
Khin Maung Lwin
Niklas Lindegardh
Sakchai Khrutsawadchai
Elizabeth Ashley
Nicholas P.J. Day
Pratap Singhasivanon
Joel Tarning
Nicholas J. White
François Nosten
Mahidol University
Nuffield Department of Clinical Medicine
Shoklo Malaria Research Unit
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2011
Citation: Antimicrobial Agents and Chemotherapy. Vol.55, No.9 (2011), 3971-3976
Abstract: Dihydroartemisinin-piperaquine is a new, highly effective, and well-Tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increase the oral bioavailability of the drug, and this has been reported for healthy volunteers. This pharmacokinetic study monitored 30 adult patients with uncomplicated falciparum malaria for 4.5 months to evaluate the effects of the concomitant intake of fat on the total piperaquine exposure. The fixed-drug combination of dihydroartemisinin-piperaquine was given with water to fasting patients (n = 15) or was coadministered with 200 ml milk containing 6.4 g fat (n = 15). The drug combination was generally well tolerated, and there were no severe adverse effects reported for either group during the study. Total piperaquine exposure (area under the concentration-time curve from zero to infinity [AUC0-∞]; results are given as medians [ranges] ) were not statistically different between fed (29.5 h · μg/ml [20.6 to 58.7 h · μg/ml]) and fasting (23.9 h · μg/ml [11.9 to 72.9 h · μg/ml] ) patients, but the interindividual variation was reduced in the fed group. Overall, none of the pharmacokinetic parameters differed statistically between the groups. Total piperaquine exposure correlated well with the day 7 concentrations in the fasted group, but the fed group showed a poor correlation. In conclusion, the coadministration of 6.4 g fat did not have any significant effect on piperaquine pharmacokinetics in the treatment of uncomplicated malaria. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80051825842&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12361
ISSN: 10986596
00664804
Appears in Collections:Scopus 2011-2015

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