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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/12402
Title: Autologous fat transplantation in patients with breast cancer: "silencing" or "fueling" cancer recurrence?
Authors: Visnu Lohsiriwat
Giuseppe Curigliano
Mario Rietjens
Aron Goldhirsch
Jean Yves Petit
Istituto Europeo di Oncologia
Mahidol University
Keywords: Medicine
Issue Date: 1-Aug-2011
Citation: Breast. Vol.20, No.4 (2011), 351-357
Abstract: Lipotransfer can be considered a technical revolution in plastic surgery and widely performed for esthetic surgery. Recently the lipofilling has been indicated in breast reconstruction and deformity correction after breast conservative treatment. However, there is lack of understanding concerning the interactions between the potential tumor beds and the lipoaspirates grafts. Current literature underlines the efficacy of the technique as well as its safety. Nevertheless, many experimental studies provide data on the endocrine, paracrine, and autocrine activities of the transplanted fat tissues. Adipocyte, pre-adipocyte and progenitor cell secretions can stimulate angiogenesis and cell growth. The "tumor-stroma interaction" can potentially induce cancer reappearance by "fueling" dormant breast cancer cells in tumor bed. There is lack of translational research that proves this concern in clinical aspect. No study on the effects of lipotransfer on human cancer breast cells in vivo is available. We provide direct and indirect effects of lipotransfer in breast cancer patients, highlighting pro and con related issues. To confirm the safety of lipotransfer in breast cancer patients we need clinical studies with control group based on long term follow up. © 2011 Elsevier Ltd.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960567239&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/12402
ISSN: 15323080
09609776
Appears in Collections:Scopus 2011-2015

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