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dc.contributor.authorNipat Simakachornen_US
dc.contributor.authorRodrigo Bibilonien_US
dc.contributor.authorPhisek Yimyaemen_US
dc.contributor.authorYothi Tongpenyaien_US
dc.contributor.authorWandee Varavithayaen_US
dc.contributor.authorDominik Grathwohlen_US
dc.contributor.authorGloria Reuteleren_US
dc.contributor.authorJean Claude Maireen_US
dc.contributor.authorStephanie Blumen_US
dc.contributor.authorPhilippe Steenhouten_US
dc.contributor.authorJalil Benyacouben_US
dc.contributor.authorEduardo J. Schiffrinen_US
dc.contributor.otherMaharaj Nakhon Ratchasima Hospitalen_US
dc.contributor.otherNestle S.A.en_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKhon Kaen Regional Hospitalen_US
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition. Vol.53, No.2 (2011), 174-181en_US
dc.description.abstractObjectives: The aim of this study was to demonstrate the tolerance and safety of an enteral formula containing prebiotics/probiotics, and its effect on the faecal microbiota in critically ill children. Subjects and Methods: Ninety-four patients between 1 and 3 years old under mechanical ventilation requiring enteral feeding were randomised to receive either a test formula containing a synbiotic blend (composed of 2 probiotic strains [Lactobacillus paracasei NCC 2461 and Bifidobacterium longum NCC 3001], fructooligosaccharides [FOS] , inulin, and Acacia gum), or a control formula. Patients remained in the intensive care unit for 7 days and were examined at day 14. Tolerance was assessed by overall caloric intake and time to reach caloric goal. Safety was assessed by abdominal distention, vomiting, and stool frequency. Microbiota was analysed by culture- and molecular-based methods. Results: Overall caloric intake and time to reach caloric goal were similar between groups (noninferiority was shown). Abdominal distention, vomiting, and stool frequency were not affected by the supplementation with pre- and probiotics. Faecal bifidobacteria were higher in the test group at the end of the study. A similar trend was observed for total lactobacilli. L paracasei NCC 2461 and B longum NCC 3001 were detected in 80.4% and 17% of the test group patients, respectively. Enterobacteria levels remained unchanged during hospitalisation in the control group but diminished in the test group. Conclusions: The enteral formula supplemented with synbiotics was well tolerated by children in intensive care units; it was safe and produced an increase in faecal bacterial groups of previously reported beneficial effects. Copyright © 2011 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.en_US
dc.rightsMahidol Universityen_US
dc.titleTolerance, safety, and effect on the faecal microbiota of an enteral formula supplemented with pre- and probiotics in critically ill childrenen_US
Appears in Collections:Scopus 2011-2015

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