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Title: Valacyclovir for herpes simplex encephalitis
Authors: Thomas Pouplin
Julie Nguyen Pouplin
Pham Van Toi
Niklas Lindegardh
H. Rogier Van Doorn
Tran Tinh Hien
Jeremy Farrar
M. Estée Török
Tran Thi Hong Chau
Cambridge University Hospitals NHS Foundation Trust
Mahidol University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2011
Citation: Antimicrobial Agents and Chemotherapy. Vol.55, No.7 (2011), 3624-3626
Abstract: The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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