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Title: Iron absorption in hepcidin1 knockout mice
Authors: Patarabutr Masaratana
Abas H. Laftah
Gladys O. Latunde-Dada
Sophie Vaulont
Robert J. Simpson
Andrew T. McKie
King's College London
Mahidol University
Institut Cochin
Keywords: Medicine;Nursing
Issue Date: 14-Jun-2011
Citation: British Journal of Nutrition. Vol.105, No.11 (2011), 1583-1591
Abstract: Hepcidin, the Fe-regulatory peptide, has been shown to inhibit Fe absorption and reticuloendothelial Fe recycling. The present study was conducted to explore the mechanism of in vivo Fe regulation through genetic disruption of hepcidin1 and acute effects of hepcidin treatment in hepcidin1 knockout (Hepc1 -/- ) and heterozygous mice. Hepcidin1 disruption resulted in significantly increased intestinal Fe uptake. Hepcidin injection inhibited Fe absorption in both genotypes, but the effects were more evident in the knockout mice. Hepcidin administration was also associated with decreased membrane localisation of ferroportin in the duodenum, liver and, most significantly, in the spleen of Hepc1 -/- mice. Hypoferraemia was induced in heterozygous mice by hepcidin treatment, but not in Hepc1 -/- mice, 4 h after injection. Interestingly, Fe absorption and serum Fe levels in Hepc1 -/- and heterozygous mice fed a low-Fe diet were not affected by hepcidin injection. The present study demonstrates that hepcidin deficiency causes increased Fe absorption. The effects of hepcidin were abolished by dietary Fe deficiency, indicating that the response to hepcidin may be influenced by dietary Fe level or Fe status. © 2011 The Authors.
ISSN: 14752662
Appears in Collections:Scopus 2011-2015

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