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dc.contributor.authorIlse C.E. Hendriksenen_US
dc.contributor.authorGeorge Mtoveen_US
dc.contributor.authorAlínia José Pedroen_US
dc.contributor.authorErmelinda Gomesen_US
dc.contributor.authorKamolrat Silamuten_US
dc.contributor.authorSue J. Leeen_US
dc.contributor.authorAbraham Mwambulien_US
dc.contributor.authorSamwel Gesaseen_US
dc.contributor.authorHugh Reyburnen_US
dc.contributor.authorNicholas P.J. Dayen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorLorenz Von Seidleinen_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherNational Institute for Medical Research Tangaen_US
dc.contributor.otherJoint Malaria Programmeen_US
dc.contributor.otherHospital Central da Beiraen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.identifier.citationClinical Infectious Diseases. Vol.52, No.9 (2011), 1100-1107en_US
dc.description.abstractBackground. Rapid diagnostic tests (RDTs) now play an important role in the diagnosis of falciparum malaria in many countries where the disease is endemic. Although these tests have been extensively evaluated in uncomplicated falciparum malaria, reliable data on their performance for diagnosing potentially lethal severe malaria is lacking. Methods. We compared a Plasmodium falciparum histidine-rich-protein2 (PfHRP 2 )-based RDT and a Plasmodium lactate dehydrogenase (pLDH)-based RDT with routine microscopy of a peripheral blood slide and expert microscopy as a reference standard for the diagnosis of severe malaria in 1898 children who presented with severe febrile illness at 2 centers in Mozambique and Tanzania. Results. The overall sensitivity, specificity, positive predictive value, and negative predictive values of the PfHRP2-based test were 94.0%, 70.9%, 85.4%, and 86.8%, respectively, and for the pLDH-based test, the values were 88.0%, 88.3%, 93.2%, and 80.3%, respectively. At parasite counts < 1000 parasites/μL (n = 173), sensitivity of the pLDH-based test was low (45.7%), compared with that of the PfHRP2-based test (69.9%). Both RDTs performed better than did the routine slide reading in a clinical laboratory as assessed in 1 of the centers. Conclusion. The evaluated PfHRP2-based RDT is an acceptable alternative to routine microscopy for diagnosing severe malaria in African children and performed better than did the evaluated pLDH-based RDT. © 2011 The Author.en_US
dc.rightsMahidol Universityen_US
dc.titleEvaluation of a PfHRP<inf>2</inf>and a pLDH-based rapid diagnostic test for the diagnosis of severe malaria in 2 populations of african childrenen_US
Appears in Collections:Scopus 2011-2015

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