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Title: Paclitaxel-eluting balloon angioplasty and cobalt-chromium stents versus conventional angioplasty and paclitaxel-eluting stents in the treatment of native coronary artery stenoses in patients with diabetes mellitus
Authors: Rosli Mohd Ali
Ralf Degenhardt
Robaayah Zambahari
Damras Tresukosol
Wan Azman Wan Ahmad
Haizal Bin Haron Kamar
Sim Kui-Hian
Tiong Kiam Ong
Omar Bin Ismail
Safari Bin Elis
Wasan Udychalerm
Hanns Ackermann
Michael Boxberger
Martin Unverdorben
Institut Jantung Negara Kuala Lumpur
Center for Cardiovascular Diseases
Mahidol University
University of Malaya Medical Centre
Sarawak Hospital
Penang Hospital
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Goethe-Universitat Frankfurt am Main
Vascular System
B. Braun Medical Inc.
Keywords: Medicine
Issue Date: 1-May-2011
Citation: EuroIntervention. Vol.7, No.SUPPL. K (2011)
Abstract: Aims: Coronary lesions in diabetics (DM) are associated with a high recurrence following percutaneous coronary intervention (PCI), even after drug-eluting stent (DES) deployment. Encouraging clinical data of the drug-eluting balloon catheter (DEB) SeQuent Please warrant its investigation in these patients. Methods and results: Eighty-four diabetic patients (60.8±9.1years, 76.2% male) were randomised to either the DEB SeQuent™ Please or the DES Taxus™ Liberte™ to compare the 9-month clinical and angiographic outcome of PCI in native coronary arteries. Comparing the DEB vs. the DES the 9-month results (follow-up DEB 39/45 [86.7%], DES 36/39 [92.3%] ) are statistically not different at the 0.05 level for the primary end- point of in-segment (0.37±0.59 mm vs. 0.35 ±0.63 mm) and in-stent (0.51±0.61 mm vs. 0.53±0.67 mm) late lumen loss, overall and cardiac deaths (2/45 [4.4%] and 3/45 [6.7%] vs. 0), target lesion revascularisation (3/45 [8.9%] vs. 4/39 [10.3%] ), the total MACE rate (6/45 [13.3%] vs. 6/39 [15.4%] ), and the event free survival after 10.2±3.8 months (Kaplan-Meier analysis, p < 0.80, log rank test). Conclusions: The clinical and angiographic outcome of the combination of the drug-eluting balloon SeQuent Please with a cobalt chromium stent compared to the drug eluting Taxus stent are similar. © Europa Edition 2011. All rights reserved.
ISSN: 19696213
Appears in Collections:Scopus 2011-2015

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