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|Title:||Paclitaxel-eluting balloon angioplasty and cobalt-chromium stents versus conventional angioplasty and paclitaxel-eluting stents in the treatment of native coronary artery stenoses in patients with diabetes mellitus|
|Authors:||Rosli Mohd Ali|
Wan Azman Wan Ahmad
Haizal Bin Haron Kamar
Tiong Kiam Ong
Omar Bin Ismail
Safari Bin Elis
Institut Jantung Negara Kuala Lumpur
Center for Cardiovascular Diseases
University of Malaya Medical Centre
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Goethe-Universitat Frankfurt am Main
B. Braun Medical Inc.
|Citation:||EuroIntervention. Vol.7, No.SUPPL. K (2011)|
|Abstract:||Aims: Coronary lesions in diabetics (DM) are associated with a high recurrence following percutaneous coronary intervention (PCI), even after drug-eluting stent (DES) deployment. Encouraging clinical data of the drug-eluting balloon catheter (DEB) SeQuent Please warrant its investigation in these patients. Methods and results: Eighty-four diabetic patients (60.8±9.1years, 76.2% male) were randomised to either the DEB SeQuent™ Please or the DES Taxus™ Liberte™ to compare the 9-month clinical and angiographic outcome of PCI in native coronary arteries. Comparing the DEB vs. the DES the 9-month results (follow-up DEB 39/45 [86.7%], DES 36/39 [92.3%] ) are statistically not different at the 0.05 level for the primary end- point of in-segment (0.37±0.59 mm vs. 0.35 ±0.63 mm) and in-stent (0.51±0.61 mm vs. 0.53±0.67 mm) late lumen loss, overall and cardiac deaths (2/45 [4.4%] and 3/45 [6.7%] vs. 0), target lesion revascularisation (3/45 [8.9%] vs. 4/39 [10.3%] ), the total MACE rate (6/45 [13.3%] vs. 6/39 [15.4%] ), and the event free survival after 10.2±3.8 months (Kaplan-Meier analysis, p < 0.80, log rank test). Conclusions: The clinical and angiographic outcome of the combination of the drug-eluting balloon SeQuent Please with a cobalt chromium stent compared to the drug eluting Taxus stent are similar. © Europa Edition 2011. All rights reserved.|
|Appears in Collections:||Scopus 2011-2015|
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